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M9490763.TXT
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1994-09-24
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Document 0763
DOCN M9490763
TI The effect of alcohol consumption on nutritional status during murine
AIDS.
DT 9411
AU Wang Y; Liang B; Watson RR; Department of Family and Community Medicine,
University of; Arizona, Tucson 85724.
SO Alcohol. 1994 May-Jun;11(3):273-8. Unique Identifier : AIDSLINE
MED/94338580
AB As alcohol (ETOH) abusers and AIDS patients have nutritional disorders,
the influence of chronic ETOH consumption (5% v/v for 10 weeks) on
levels of immunomodulatory nutrients (vitamins A and E, Zn, and Cu) in
the serum, liver, small intestine, spleen, and thymus was determined
during murine AIDS. The hepatic levels of vitamins A and E and Zn in
both normal and LP-BM5 retrovirus-infected female C56BL/6 mice fed ETOH
were significantly reduced compared to controls, whereas the level of Cu
in the liver was not affected. Intestinal levels of vitamin A and Cu
were not affected by ETOH, whereas vitamin E and Zn were significantly
reduced in both normal mice and those with AIDS fed ETOH. The splenic
levels of vitamin A and Zn in the normal mice were significantly reduced
by ETOH compared to controls, but vitamin E and Cu were not. All splenic
levels of nutrients measured were reduced in ETOH-fed mice with AIDS.
The levels of vitamins A and E, Zn, and Cu in the thymus in murine AIDS
were also significantly affected by ETOH consumption. The serum levels
of vitamins A and E in both normal mice and murine AIDS were
significantly decreased by dietary ETOH. These data produced evidence
that chronic ETOH can directly aggravate undernutrition initiated by
retrovirus infection. Such ETOH-induced malnutrition in AIDS may be a
cofactor, accelerating development of AIDS via immunosuppression
secondary to nutritional deficiencies.
DE Alcohol, Ethyl/ADMINISTRATION & DOSAGE/*PHARMACOLOGY Animal
Copper/BLOOD/METABOLISM Female Intestines/DRUG EFFECTS/METABOLISM
Liver/DRUG EFFECTS/METABOLISM Mice Mice, Inbred C57BL Murine Acquired
Immunodeficiency Syndrome/*PHYSIOPATHOLOGY *Nutritional Status
Spleen/DRUG EFFECTS/METABOLISM Support, U.S. Gov't, P.H.S. Thymus
Gland/DRUG EFFECTS/METABOLISM Vitamin A/BLOOD/METABOLISM Vitamin
E/BLOOD/METABOLISM Zinc/BLOOD/METABOLISM JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).